Our overarching goal is to understand how the functions of proteins and their networks change over time. We are particularly focused on the process of co-evolution within functional networks and the ways by which proteins influence each other during evolution. We study a variety of organisms ranging from single cells to primates. Currently we perform experiments in yeast and bacteria to retrace the evolution of protein function, while our computational studies are based in yeast species, Drosophila, and mammals.
Specific Research Topics
ERC is a phylogenetic signature that reflects co-functionality between genes. We develop genome-wide datasets of ERC to provide co-evolutionary predictions and to interpret major functional shifts during evolution.
ERC Analysis webserver
Yeast genetics shows that molecular incompatibilities arise quickly between nuclear pore proteins. How does the process of compensatory co-evolution maintain these crucial protein-protein interactions?
What is driving the evolution of gamete recognition proteins in yeast? What are the implications of this divergence for reproductive isolation and speciation?
Post-copulatory interactions between males and females have been shaped by a complex set of competitive and conflictive forces, resulting in specialized male and female traits.
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