We investigate the molecular and cellular origins of human epithelial malignancies (e.g., breast cancer, Barrett’s) through computational models. We pursue two interrelated approaches:

1. Computational Pathology and Bioimaging We develop algorithms to analyze intratumor phenotypic heterogeneity from in situ fluorescent imaging of tissue sections or tissue microarrays.
2. Computational Biophysics We develop models based on anharmonic fluctuations to discern short-lived and rare intermediate conformations that proteins access to fold, bind, and function.