Ivan V. Maly
Email: ivanvmaly at gmail dot com
Diploma in Physiology, Moscow State University, 1999, with I. A. Vorobjev
Ph.D. in the Life Sciences, Northwestern University, 2002, with G. G. Borisy
Postdoctoral studies in Biological Engineering, Massachusetts Institute of Technology, with D. A. Lauffenburger
Assistant Professor, Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, 2004-2012
Present address: Department of Mathematics and Natural Sciences, D'Youville College
Books, book chapters, reviews
I.V. Maly. Systems Biomechanics of the Cell. Springer, 2013.
I.V. Maly. Cytoskeleton and Cell Motility Models: From Kinetics to Structure. VDM, 2009 (on Amazon).
Systems Biology, I.V. Maly, ed. (Methods in Molecular Biology vol. 500) Springer, 2009 (on Amazon).
I.V. Maly. Systems biomechanics of centrosome positioning: A conserved complexity. Commun. Integr. Biol. 4:230–235 (2011).
I.V. Maly. Introduction: a practical guide to the systems approach in biology. Methods Mol. Biol. 500:3–13 (2009).
Primary research papers
(over 700 citations)
I.V. Maly. Equilibria of idealized confined astral microtubules and coupled spindle poles. PLoS ONE 7(6): e38921 (2012).
I.V. Maly. Efficiency of organelle capture by microtubules as a function of centrosome nucleation capacity: general theory and the special case of polyspermia. PLoS ONE 7(5): e37675 (2012).
V.I. Maly and I.V. Maly. Symmetry, stability, and reversibility properties of idealized confined microtubule cytoskeletons. Biophys. J. 99: 2831–2840 (2010).
MJ Kim and I.V. Maly. Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets. PLoS Comput. Biol., 5: e1000260 (2009).
A. Baratt, S.N. Arkhipov, and I.V. Maly. An experimental and computational study of effects of microtubule stabilization on T-cell polarity. PLoS ONE, 3:e3861 (2008).
I.A. Vorobjev and I.V. Maly. Microtubule length and dynamics: Boundary effect and properties of extended radial array. Cell Tissue Biol., 2:272–281 (2008).
S.N. Arkhipov and I.V. Maly. Retractile processes in T lymphocyte orientation on a stimulatory substrate: morphology and dynamics. Phys. Biol., 5:016006 (2008). PubMed Central
S.N. Arkhipov and I.V. Maly. A model for the interplay of receptor recycling and receptor-mediated contact in T cells. PLoS ONE, 2:e633 (2007).
I. Grigoriev, D. Splinter, N. Keijzer, P.S. Wulf, J. Demmers, T. Ohtsuka, M. Modesti, I.V. Maly, F. Grosveld, C.C. Hoogenraad, and A. Akhmanova. Rab6 regulates transport and targeting of exocytotic carriers. Dev. Cell, 13:305–314 (2007).
S.N. Arkhipov and I.V. Maly. Quantitative analysis of the role of receptor recycling in T cell polarization. Biophys. J., 91:4306–4316 (2006).
S.N. Arkhipov and I.V. Maly. Contribution of whole-cell optimization via cell body rolling to polarization of T cells. Phys. Biol., 3:209–219 (2006). PubMed Central
I.V. Maly, R.T. Lee, and D.A. Lauffenburger. A model for mechanotransduction in cardiac muscle: effects of extracellular matrix deformation on autocrine signaling. Ann. Biomed. Eng., 32:1319–1335 (2004).
D.J. Tschumperlin, G. Dai, I.V. Maly, T. Kikuchi, L.H. Laiho, A.K. McVittie, K.J. Haley, C.M. Lilly, P.T.C. So, D.A. Lauffenburger, R.D. Kamm, and J.M. Drazen. Mechanotransduction via growth factor shedding into a compliant extracellular space. Nature, 429:83–86 (2004).
I.V. Maly, H.S. Wiley, and D.A. Lauffenburger. Self-organization of polarized cell signaling via autocrine circuits: computational model analysis. Biophys. J., 86:10–22 (2004). Cell Press PubMed Central
I.V. Maly and G.G. Borisy. Self-organization of treadmilling microtubules into a polar array. Trends Cell Biol., 12:462–465 (2002). Correct link to supplementary material
I.V. Maly and I.A. Vorobjev. Centrosome-dependent anisotropic random walk of cytoplasmic vesicles. Cell Biol. Int., 26:791–799 (2002).
J.E. Bear, T.M. Svitkina, M. Krause, D.A. Schafer, J.J. Loureiro, G.A. Strasser, I.V. Maly, O.Y. Chaga, J.A. Cooper, G.G. Borisy, and F.B. Gertler. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell, 109:509–521 (2002).
I.V. Maly. A stochastic model for patterning of the cytoplasm by the saltatory movement. J. Theor. Biol., 216:59–71 (2002).
I.V. Maly. Diffusion approximation of the stochastic process of microtubule assembly. Bull. Math. Biol., 64:213–238 (2002).
I.V. Maly and G.G. Borisy. Self-organization of a propulsive actin network as an evolutionary process. Proc. Natl. Acad. Sci. USA, 98:11324–11329 (2001).
I.A. Vorobjev, V.I. Rodionov, I.V. Maly, and G.G. Borisy. Contribution of plus and minus end pathways to microtubule turnover. J. Cell Sci., 112:2277–2289 (1999).
"Quantitative Study of T-Cell Polarization". NIH R01 grant. Sole PI. 2006-2011.
"Spatial Organization of Cadherin Junctions by Dynamic Microtubules: An Integrated Model". Program grant from Human Frontier Science Program. 1 of 4 PIs. 2008-2012.
Updated June 21, 2012