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Student Spotlight Heading 1pixel Recent Publications image 1pixel Research Progress Heading

Anindita Dutta's recent award for the "Outstanding Student Researcher in the Department of Computational & Systems Biology of 2012".

Anindita Dutta Award

Congratulations to Lidio Meireles, Ying Liu, and Lin Liu on their successful defenses!

Lidio was first author on the Protein Science article that became the cover of the September 2011 issue, "Pre-existing soft modes of motion uniquely defined by native contact topology facilitate ligand binding to proteins", along with lab members Dr. Mert Gur, Dr. Ahmet Bakan, and Dr. Ivet Bahar.

Protein Science Cover

Ahmet Bakan's recent PNAS paper on drug binding mechanisms vs. intrinsic changes in shape(PDF).

See also his paper: "In vivo chemical screen in zebrafish reveals a novel modulator of FGF signaling"

and related commentaries: " Small molecule inhibitors: Another one bites the Dusp."

Another one bites the Dusp

Zheng Yang's study on GroEL machinery became the cover illustration for Molecular Biosystems

 

Dr. Lee Wei Yang, a former graduate student has recieved the Stephen L. Phillips Award
...read interview

 

"2007 Outstanding Student Researcher Award" : Basak Isin
(click to see full image) dunno
Former student Lee-Wei Yang published article in Pitt magazine " Investigations: Explorations and revalations taking place in the medical school"
...view article

 

  

Publications 2012

Pitt, CMU, Supercomputing Center win grant for biomedical technology. December 3, 2012. Pittsburgh Post-Gazette.

"Allosteric Transitions of Supramolecular Systems Explored by Network Models: Application to Chaperonin GroEL." Yang, Z., Majek, P., & Bahar, I. (2009). PLoS Comput Biol. 5: e100360. PMID: 19381265.

Comput Biol 5(4) cover

"Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter." Gu, Y., Shrivastava, I. H., Amara, S. G., & Bahar, I. (2009). Proc Natl Acad Sci U.S.A.. 106: 2589-94. PMID: 19202063.

"Signal propagation in proteins and relation to equilibrium fluctuations." Chennubhotla C, Bahar I. PLoS Comput Biol. 2007 Sep 21;3(9):1716-26.

"Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulation." Chennubhotla C, Bahar I., Tobi D. (2007) Curr Opin Struct Biol. 17:633-40.

Noraml Mode Analysis Book

Recent applications have shown the applicability of normal mode analysis (NMA) to macromolecular assemblies...

...find out more

Book Review in Briefings in Bioinformatics

 

 

"Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter." Gu Y, Shrivastava IH, Amara SG, Bahar I. (2009) Proc Natl Acad Sci U S A. 106:2589-94

Protein Science cover